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Meg Ryan has published a heartfelt tribute to the deceased director Rob Reiner, under whose direction she worked in the beloved rom-com When Harry Met Sally.

A Heartbreaking Event

Reiner was discovered deceased alongside his spouse, Michele Singer Reiner, at their Los Angeles home this past weekend.

“We will miss this man so deeply…” Ryan wrote on Instagram, next to an image of them together. “We thank you, Rob and Michele, for your belief in true love, fairy tales, and laughter. We appreciate your faith in human goodness and your deep patriotism.”

Court Case Developments

Reiner’s son Nick, 32, is accused of two counts of first-degree murder and made a court appearance today. He’s being incarcerated with no bail set. Sources state that Reiner’s daughter Romy discovered her father deceased.

“It is my belief that from this horror, positive change and understanding can emerge,” Ryan went on to write. “I don’t know, but my guess is that they would want that to be hopeful and humane, to be something that brings us all to a greater understanding of one another and to some peace.”

Family Members Issue a Message

Reiner’s surviving children Jake and Romy released a message today. “Language fails to capture the daily agony we endure,” they said. “The tragic, shattering loss of our parents is an experience no one should have to face. They weren’t just our parents; they were our best friends.”

Colleagues and Friends Remember

Ryan’s co-star, Billy Crystal, similarly honored Reiner through a message shared yesterday together with remarks by Larry David, Martin Short and Albert Brooks.

“No one matched his comic instinct, his dedication to rhythmic dialogue, or his elegant sharpening of drama,” the statement said. “For the actors, he loved them. For the writers he made them better. His finest trait was granting creative liberty. He valued input and made you part of the team. Everyone felt like part of a crew. His direction was a gift, but his legacy is broader.”

A Storied Career

When Harry Met Sally was a box office and critical triumph in 1989, grossing more than $93 million worldwide and earning Nora Ephron an Oscar nomination for best original screenplay.

Rob Reiner first encountered Michele Singer Reiner while making When Harry Met Sally. The pair were brought together by Barry Sonnenfeld, a fellow filmmaker and pal.

Reiner’s extensive filmography featured classics such as Misery, Stand by Me and The Princess Bride. The director and his wife were together in marriage for 36 years.